Setting description

Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
—+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
-+– param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+–+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
++– param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
TP53+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
DRD+ param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 9.9, median = 7.1 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 1.13, hr = 0.88 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 25, median = 18 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 2.85, hr = 0.33 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 3 3 0 1
TP53- & AR- 272 5 2 2
TP53+ 1 12 3 4
DRD+ 0 3 166 159
TEfus+ 1 167 1 3
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.006 0.006 0.000 0.002
TP53- & AR- 0.544 0.010 0.004 0.004
TP53+ 0.002 0.024 0.006 0.008
DRD+ 0.000 0.006 0.332 0.318
TEfus+ 0.002 0.334 0.002 0.006
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 1 0 0 0
TP53- & AR- 0 105 122 110
TP53+ 254 0 3 3
DRD+ 75 7 0 0
TEfus+ 93 0 6 11
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.002 0.000 0.000 0.000
TP53- & AR- 0.000 0.210 0.244 0.220
TP53+ 0.508 0.000 0.006 0.006
DRD+ 0.150 0.014 0.000 0.000
TEfus+ 0.186 0.000 0.012 0.022
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 8 11 14 17
TP53+ 1 9 14 13
DRD+ 0 0 0 0
TEfus+ 0 1 0 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.016 0.022 0.028 0.034
TP53+ 0.002 0.018 0.028 0.026
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.002 0.000 0.004


Errors & power

The overall error was 0.048.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.008             0.026             0.006             0.008 

The overall power was 0.858.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.544             0.334             0.332             0.318 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 3 3 0 1
futility 0 1 0 0 0
max_n 0 0 0 0 0
n 276 (244, 311) 186 (121, 253) 236 (177, 287) 248 (180, 292) 244 (182, 292)
n_unique 252 (226, 284) 167 (106, 230) 216 (160, 262) 225 (164, 266) 221 (165, 268)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 4 (4, 4) 4 (4, 5) NA (NA, NA) 5 (5, 5)
post_p NA (NA, NA) 0.47 (0.02, 0.98) 0.53 (0.06, 0.94) 0.24 (0.01, 0.71) 0.23 (0.01, 0.71)
rate 0.093 (0.084, 0.102) 0.092 (0.075, 0.115) 0.092 (0.079, 0.109) 0.1 (0.09, 0.115) 0.101 (0.09, 0.114)
TP53- & AR- graduation 0 272 5 2 2
futility 0 0 105 122 110
max_n 0 8 11 14 17
n 115 (96, 143) 73 (26, 116) 100 (32, 131) 100 (30, 130) 100 (31, 129)
n_unique 106 (88, 133) 68 (24, 106) 92 (29, 120) 92 (28, 117) 91 (28, 118)
time_trial 36 (36, 36) 29 (9, 36) 36 (13, 36) 36 (12, 36) 36 (12, 36)
time_stop NA (NA, NA) 12 (9, 28) 13 (9, 23) 13 (9, 23) 13 (9, 21)
post_p NA (NA, NA) 1 (0.93, 1) 0.02 (0, 0.2) 0.02 (0, 0.24) 0.02 (0, 0.2)
rate 0.073 (0.062, 0.085) 0.042 (0.034, 0.051) 0.109 (0.09, 0.134) 0.106 (0.088, 0.128) 0.105 (0.09, 0.13)
TP53+ graduation 0 1 12 3 4
futility 0 254 0 3 3
max_n 0 1 9 14 13
n 119 (103, 138) 89 (33, 119) 108 (78, 133) 114 (90, 137) 113 (91, 136)
n_unique 108 (93, 127) 81 (30, 108) 97 (72, 120) 104 (82, 124) 102 (82, 124)
time_trial 36 (36, 36) 35 (12, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 18 (10, 32) 11 (8, 16) 12 (10, 18) 11 (9, 14)
post_p NA (NA, NA) 0.02 (0, 0.13) 0.96 (0.63, 1) 0.7 (0.22, 0.97) 0.69 (0.22, 0.97)
rate 0.112 (0.098, 0.129) 0.162 (0.138, 0.194) 0.084 (0.069, 0.105) 0.103 (0.088, 0.12) 0.103 (0.088, 0.123)
DRD+ graduation 0 0 3 166 159
futility 0 75 7 0 0
max_n 0 0 0 0 0
n 82 (67, 99) 52 (31, 77) 68 (45, 93) 67 (28, 90) 67 (30, 89)
n_unique 76 (61, 92) 46 (27, 71) 60 (40, 83) 60 (25, 81) 61 (27, 80)
time_trial 36 (36, 36) 36 (22, 36) 36 (36, 36) 36 (16, 36) 36 (16, 36)
time_stop NA (NA, NA) 20 (14, 32) 17 (13, 33) 20 (12, 32) 20 (13, 32)
post_p NA (NA, NA) 0.15 (0.01, 0.64) 0.52 (0.12, 0.92) 1 (0.99, 1) 1 (0.99, 1)
rate 0.089 (0.074, 0.107) 0.099 (0.076, 0.135) 0.079 (0.061, 0.1) 0.036 (0.027, 0.044) 0.035 (0.027, 0.044)
TEfus+ graduation 0 1 167 1 3
futility 0 93 0 6 11
max_n 0 0 1 0 2
n 105 (87, 124) 70 (36, 101) 86 (28, 114) 94 (69, 119) 91 (69, 118)
n_unique 96 (80, 114) 63 (32, 89) 77 (25, 101) 85 (63, 107) 83 (62, 107)
time_trial 36 (36, 36) 36 (22, 36) 36 (12, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 22 (11, 35) 15 (10, 31) 13 (12, 26) 16 (9, 24)
post_p NA (NA, NA) 0.02 (0, 0.23) 1 (0.98, 1) 0.16 (0.01, 0.55) 0.17 (0.02, 0.55)
rate 0.074 (0.063, 0.086) 0.11 (0.086, 0.139) 0.038 (0.03, 0.046) 0.09 (0.073, 0.109) 0.088 (0.073, 0.107)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 276 113 124 113
futility 0 0 0 0 0
max_n 0 8 11 14 17
n 70 (55, 88) 47 (16, 72) 62 (22, 83) 62 (19, 81) 63 (20, 81)
n_unique 64 (50, 84) 44 (15, 68) 58 (21, 78) 58 (18, 76) 59 (19, 75)
post_p NA (NA, NA) 1 (0.96, 1) 0 (0, 0.06) 0 (0, 0.06) 0 (0, 0.05)
rate 0.083 (0.067, 0.101) 0.043 (0.032, 0.056) 0.158 (0.132, 0.193) 0.158 (0.132, 0.193) 0.161 (0.135, 0.191)
—+ graduation 0 343 256 128 122
futility 0 0 0 0 0
max_n 0 8 12 14 17
n 15 (10, 22) 7 (2, 17) 10 (2, 18) 14 (4, 20) 13 (4, 21)
n_unique 14 (9, 20) 6 (2, 15) 9 (2, 17) 12 (3, 18) 12 (4, 19)
post_p NA (NA, NA) 0.75 (0.41, 0.96) 0.83 (0.43, 0.97) 0.04 (0, 0.23) 0.05 (0, 0.25)
rate 0.051 (0.03, 0.081) 0.044 (0.021, 0.08) 0.038 (0.02, 0.075) 0.161 (0.109, 0.266) 0.159 (0.105, 0.261)
–+- graduation 0 259 15 6 8
futility 0 0 0 0 0
max_n 0 1 9 14 13
n 38 (29, 46) 29 (10, 41) 37 (28, 46) 37 (28, 46) 38 (28, 47)
n_unique 34 (26, 43) 27 (10, 37) 34 (25, 42) 34 (26, 43) 34 (26, 43)
post_p NA (NA, NA) 0.4 (0.09, 0.78) 0.38 (0.07, 0.79) 0.4 (0.07, 0.82) 0.37 (0.07, 0.8)
rate 0.146 (0.115, 0.181) 0.163 (0.127, 0.224) 0.161 (0.129, 0.202) 0.159 (0.128, 0.206) 0.163 (0.128, 0.206)
–++ graduation 0 305 177 12 22
futility 0 0 0 0 0
max_n 0 1 10 14 14
n 26 (19, 34) 18 (7, 30) 22 (8, 31) 27 (19, 35) 26 (18, 34)
n_unique 24 (17, 32) 16 (6, 27) 20 (7, 28) 24 (17, 33) 24 (17, 31)
post_p NA (NA, NA) 0.08 (0.01, 0.32) 0.99 (0.9, 1) 0.05 (0, 0.27) 0.06 (0, 0.27)
rate 0.085 (0.059, 0.122) 0.161 (0.12, 0.23) 0.039 (0.022, 0.055) 0.156 (0.121, 0.201) 0.158 (0.119, 0.206)
-+– graduation 0 328 122 252 249
futility 0 0 0 0 0
max_n 0 8 11 11 17
n 15 (9, 21) 7 (2, 17) 13 (4, 20) 10 (3, 18) 10 (3, 19)
n_unique 14 (8, 20) 6 (2, 15) 12 (4, 18) 9 (3, 16) 10 (3, 17)
post_p NA (NA, NA) 0.77 (0.43, 0.93) 0.05 (0, 0.26) 0.86 (0.51, 0.98) 0.85 (0.53, 0.98)
rate 0.08 (0.053, 0.125) 0.043 (0.021, 0.081) 0.162 (0.104, 0.228) 0.035 (0.018, 0.069) 0.037 (0.02, 0.067)
-+-+ graduation 0 376 262 255 255
futility 0 0 0 0 0
max_n 0 8 12 11 17
n 16 (10, 23) 6 (2, 18) 10 (3, 20) 10 (3, 21) 11 (3, 20)
n_unique 15 (9, 21) 5 (2, 15) 9 (2, 18) 9 (3, 18) 10 (3, 18)
post_p NA (NA, NA) 0.55 (0.25, 0.81) 0.58 (0.26, 0.88) 0.63 (0.28, 0.88) 0.63 (0.3, 0.88)
rate 0.053 (0.032, 0.079) 0.042 (0.018, 0.079) 0.039 (0.018, 0.069) 0.037 (0.018, 0.066) 0.036 (0.018, 0.064)
-++- graduation 0 294 25 170 164
futility 0 0 0 0 0
max_n 0 1 9 14 11
n 8 (4, 12) 5 (2, 11) 8 (4, 13) 7 (3, 11) 7 (3, 12)
n_unique 7 (4, 11) 5 (1, 10) 7 (3, 11) 6 (2, 11) 6 (2, 11)
post_p NA (NA, NA) 0.28 (0.09, 0.55) 0.25 (0.04, 0.53) 0.93 (0.69, 0.99) 0.92 (0.69, 0.99)
rate 0.151 (0.087, 0.267) 0.168 (0.101, 0.36) 0.167 (0.094, 0.283) 0.034 (0.013, 0.07) 0.035 (0.015, 0.071)
-+++ graduation 0 329 184 175 175
futility 0 0 0 0 0
max_n 0 1 10 14 12
n 9 (5, 13) 5 (1, 10) 7 (2, 12) 7 (3, 12) 7 (2, 12)
n_unique 8 (5, 13) 4 (1, 9) 6 (2, 11) 6 (2, 11) 6 (2, 11)
post_p NA (NA, NA) 0.16 (0.03, 0.38) 0.73 (0.46, 0.93) 0.76 (0.46, 0.93) 0.76 (0.45, 0.94)
rate 0.087 (0.044, 0.158) 0.164 (0.097, 0.378) 0.038 (0.015, 0.077) 0.034 (0.013, 0.072) 0.035 (0.013, 0.078)
+— graduation 0 4 3 0 1
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (7, 17) 12 (7, 16) 12 (8, 17) 12 (8, 17) 12 (8, 17)
n_unique 11 (6, 15) 10 (6, 15) 11 (7, 16) 11 (7, 15) 11 (7, 16)
post_p NA (NA, NA) 0.42 (0.12, 0.81) 0.47 (0.12, 0.84) 0.47 (0.14, 0.82) 0.46 (0.12, 0.8)
rate 0.145 (0.093, 0.222) 0.166 (0.112, 0.257) 0.16 (0.106, 0.254) 0.155 (0.104, 0.24) 0.161 (0.11, 0.252)
+–+ graduation 0 98 170 7 15
futility 0 0 0 0 0
max_n 0 0 1 0 2
n 10 (6, 15) 9 (4, 15) 8 (3, 14) 10 (6, 15) 10 (6, 14)
n_unique 9 (6, 14) 8 (4, 13) 7 (2, 12) 9 (5, 14) 9 (5, 13)
post_p NA (NA, NA) 0.21 (0.04, 0.53) 0.94 (0.67, 1) 0.2 (0.03, 0.51) 0.2 (0.04, 0.52)
rate 0.087 (0.048, 0.153) 0.166 (0.102, 0.278) 0.038 (0.017, 0.076) 0.163 (0.106, 0.255) 0.168 (0.107, 0.267)
+-+- graduation 0 259 15 6 8
futility 0 0 0 0 0
max_n 0 1 9 14 13
n 10 (6, 15) 8 (2, 13) 10 (6, 14) 10 (6, 15) 10 (5, 14)
n_unique 9 (5, 13) 6 (2, 11) 9 (5, 13) 9 (5, 13) 9 (5, 13)
post_p NA (NA, NA) 0.42 (0.17, 0.76) 0.48 (0.16, 0.81) 0.46 (0.15, 0.8) 0.47 (0.16, 0.81)
rate 0.151 (0.095, 0.236) 0.175 (0.115, 0.34) 0.157 (0.104, 0.249) 0.16 (0.105, 0.268) 0.16 (0.107, 0.261)
+-++ graduation 0 305 177 12 22
futility 0 0 0 0 0
max_n 0 1 10 14 14
n 11 (7, 16) 7 (2, 12) 8 (3, 14) 11 (7, 16) 10 (6, 16)
n_unique 10 (6, 14) 6 (2, 12) 7 (2, 13) 10 (6, 14) 9 (5, 14)
post_p NA (NA, NA) 0.24 (0.06, 0.5) 0.94 (0.66, 0.99) 0.19 (0.04, 0.49) 0.19 (0.04, 0.49)
rate 0.087 (0.05, 0.152) 0.173 (0.107, 0.336) 0.039 (0.018, 0.078) 0.16 (0.109, 0.253) 0.164 (0.107, 0.262)
++– graduation 0 79 13 166 160
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 8 (5, 12) 7 (4, 12) 8 (4, 12) 6 (3, 11) 6 (3, 11)
n_unique 7 (4, 11) 7 (3, 11) 7 (4, 11) 6 (2, 10) 6 (2, 10)
post_p NA (NA, NA) 0.24 (0.07, 0.5) 0.24 (0.07, 0.57) 0.92 (0.67, 0.99) 0.91 (0.69, 0.99)
rate 0.152 (0.09, 0.261) 0.167 (0.1, 0.311) 0.158 (0.095, 0.293) 0.035 (0.013, 0.077) 0.036 (0.015, 0.073)
++-+ graduation 0 147 177 172 171
futility 0 0 0 0 0
max_n 0 0 1 0 2
n 8 (5, 13) 7 (3, 11) 7 (2, 12) 7 (2, 11) 7 (2, 12)
n_unique 8 (4, 12) 6 (2, 10) 6 (2, 11) 6 (2, 10) 6 (2, 11)
post_p NA (NA, NA) 0.13 (0.02, 0.34) 0.76 (0.44, 0.93) 0.76 (0.48, 0.94) 0.78 (0.45, 0.94)
rate 0.089 (0.044, 0.169) 0.166 (0.099, 0.304) 0.037 (0.017, 0.08) 0.035 (0.014, 0.069) 0.036 (0.014, 0.073)
+++- graduation 0 294 25 170 164
futility 0 0 0 0 0
max_n 0 1 9 14 11
n 8 (5, 13) 5 (2, 10) 8 (4, 13) 7 (3, 11) 7 (3, 12)
n_unique 8 (4, 12) 5 (1, 9) 7 (3, 11) 6 (2, 10) 6 (2, 11)
post_p NA (NA, NA) 0.27 (0.09, 0.53) 0.24 (0.06, 0.58) 0.92 (0.69, 0.99) 0.93 (0.72, 0.99)
rate 0.153 (0.088, 0.265) 0.173 (0.101, 0.343) 0.159 (0.096, 0.268) 0.035 (0.015, 0.069) 0.034 (0.012, 0.069)
++++ graduation 0 329 184 175 175
futility 0 0 0 0 0
max_n 0 1 10 14 12
n 9 (5, 13) 5 (2, 10) 7 (2, 12) 7 (3, 13) 7 (3, 12)
n_unique 8 (4, 12) 5 (1, 9) 6 (2, 11) 6 (2, 11) 6 (2, 11)
post_p NA (NA, NA) 0.17 (0.03, 0.36) 0.75 (0.44, 0.93) 0.78 (0.46, 0.95) 0.78 (0.46, 0.95)
rate 0.094 (0.047, 0.181) 0.173 (0.093, 0.373) 0.04 (0.015, 0.078) 0.034 (0.013, 0.074) 0.034 (0.013, 0.069)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 3 3 1
time_stop 4 (4, 4) 4 (4, 5) 5 (5, 5)
n_trt 28 (26, 29) 27 (25, 32) 33 (33, 33)
n_control 24 (22, 30) 24 (17, 35) 23 (23, 23)
post_p 0.9 (0.86, 0.91) 0.97 (0.92, 0.97) 0.9 (0.9, 0.9)
order 1 (1, 1) 1 (1, 1) 1 (1, 1)
TP53- & AR- count 272 5 2 2
time_stop 12 (9, 28) 11 (8, 12) 9 (8, 10) 12 (12, 13)
n_trt 30 (25, 81) 28 (25, 34) 26 (25, 28) 38 (36, 40)
n_control 33 (20, 81) 27 (25, 31) 22 (20, 24) 34 (32, 36)
post_p 0.98 (0.91, 1) 0.88 (0.86, 0.9) 0.95 (0.95, 0.96) 0.91 (0.88, 0.93)
order 1 (1, 2) 1 (1, 1.6) 1 (1, 1) 1.5 (1.1, 1.9)
TP53+ count 1 12 3 4
time_stop 7 (7, 7) 11 (8, 16) 11 (9, 18) 12 (10, 14)
n_trt 25 (25, 25) 32 (25, 52) 28 (26, 43) 34 (25, 43)
n_control 17 (17, 17) 37 (19, 55) 30 (27, 56) 30 (22, 36)
post_p 0.86 (0.86, 0.86) 0.98 (0.9, 0.99) 0.93 (0.91, 0.98) 0.94 (0.87, 0.98)
order 1 (1, 1) 1 (1, 2) 1 (1, 1.8) 2 (1.3, 2)
DRD+ count 3 166 159
time_stop 13 (11, 14) 20 (12, 32) 20 (13, 32)
n_trt 25 (25, 27) 34 (25, 71) 38 (26, 73)
n_control 18 (16, 24) 38 (23, 72) 39 (22, 74)
post_p 0.92 (0.9, 0.96) 1 (0.96, 1) 1 (0.97, 1)
order 2 (1.2, 2) 2 (1, 3) 2 (1, 3)
TEfus+ count 1 167 1 3
time_stop 10 (10, 10) 15 (10, 31) 14 (14, 14) 9 (7, 12)
n_trt 25 (25, 25) 34 (26, 85) 29 (29, 29) 25 (25, 33)
n_control 19 (19, 19) 36 (22, 86) 41 (41, 41) 29 (20, 31)
post_p 0.97 (0.97, 0.97) 0.99 (0.96, 1) 0.99 (0.99, 0.99) 0.94 (0.88, 0.96)
order 1 (1, 1) 1 (1, 3) 2 (2, 2) 1 (1, 1)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 1
time_stop 4 (4, 4)
n_trt 30 (30, 30)
n_control 22 (22, 22)
post_p 0.14 (0.14, 0.14)
order 1 (1, 1)
TP53- & AR- count 105 122 110
time_stop 14 (9, 24) 13 (9, 23) 13 (9, 21)
n_trt 36 (26, 70) 32 (26, 67) 32 (25, 61)
n_control 37 (23, 71) 34 (21, 73) 32 (20, 59)
post_p 0.04 (0, 0.17) 0.07 (0.01, 0.24) 0.06 (0.01, 0.24)
order 1 (1, 2) 1 (1, 2) 1 (1, 2)
TP53+ count 254 3 3
time_stop 18 (10, 32) 13 (12, 15) 11 (9, 13)
n_trt 56 (28, 99) 39 (39, 41) 38 (29, 39)
n_control 54 (25, 99) 43 (39, 47) 31 (29, 33)
post_p 0.02 (0, 0.13) 0.03 (0.03, 0.11) 0.06 (0.06, 0.24)
order 1 (1, 3) 2 (1.2, 2) 1 (1, 1.8)
DRD+ count 75 7
time_stop 20 (14, 32) 18 (16, 33)
n_trt 33 (26, 51) 33 (30, 84)
n_control 40 (23, 62) 35 (26, 73)
post_p 0.03 (0, 0.13) 0.07 (0.03, 0.13)
order 2 (1, 3) 2 (1, 3)
TEfus+ count 93 6 11
time_stop 22 (11, 35) 12 (12, 28) 19 (10, 25)
n_trt 47 (26, 83) 34 (29, 77) 39 (25, 54)
n_control 54 (24, 102) 33 (26, 75) 45 (23, 72)
post_p 0.01 (0, 0.06) 0.02 (0, 0.09) 0.04 (0.02, 0.09)
order 2 (1, 3.8) 3 (1.5, 3) 2 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 8 (6, 10) 1 (0, 1) 4 (3, 5) 3 (2, 3) 1 (0, 1) 4 (2, 5) 0 (0, 2) 0 (0, 2) 1 (0, 3) 1 (1, 3) 0 (0, 0) 0 (0, 1) 1 (0, 2) 1 (0, 3) 1 (1, 1) 0 (0, 1)
post_p 0.73 (0.68, 0.74) 0.5 (0.5, 0.5) 0.67 (0.6, 0.73) 0.6 (0.57, 0.66) 0.57 (0.54, 0.59) 0.52 (0.52, 0.52) 0.5 (0.5, 0.5) 0.58 (0.58, 0.58) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.61 (0.61, 0.61) 0.64 (0.64, 0.64) 0.56 (0.56, 0.56) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0.073) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.059 (0.012, 0.106) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.051 (0.01, 0.092) 0 (0, 1.248) 0.291 (0.291, 0.291)
Taxel_therapies count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5)
n 9 (7, 11) 2 (0, 2) 2 (1, 4) 3 (3, 4) 2 (2, 3) 0 (0, 2) 0 (0, 0) 1 (0, 1) 2 (0, 3) 1 (0, 2) 2 (1, 3) 1 (0, 3) 0 (0, 1) 0 (0, 3) 0 (0, 1) 0 (0, 1)
post_p 0.65 (0.62, 0.71) 0.56 (0.56, 0.56) 0.63 (0.6, 0.65) 0.68 (0.68, 0.7) 0.56 (0.54, 0.59) 0.6 (0.6, 0.6) NA (NA, NA) 0.53 (0.53, 0.53) 0.8 (0.76, 0.84) 0.61 (0.61, 0.61) 0.67 (0.63, 0.73) 0.55 (0.55, 0.55) 0.55 (0.55, 0.55) 0.69 (0.69, 0.69) 0.51 (0.51, 0.51) 0.57 (0.57, 0.57)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.075 (0.049, 0.099) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
n 8 (8, 8) 1 (1, 1) 4 (4, 4) 2 (2, 2) 2 (2, 2) 2 (2, 2) 2 (2, 2) 2 (2, 2) 2 (2, 2) 1 (1, 1) 1 (1, 1) 0 (0, 0) 0 (0, 0) 2 (2, 2) 2 (2, 2) 2 (2, 2)
post_p 0.67 (0.67, 0.67) 0.68 (0.68, 0.68) 0.57 (0.57, 0.57) 0.58 (0.58, 0.58) 0.55 (0.55, 0.55) 0.5 (0.5, 0.5) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.6 (0.6, 0.6) 0.61 (0.61, 0.61) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) 0.53 (0.53, 0.53) 0.64 (0.64, 0.64)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.078 (0.078, 0.078) 0 (0, 0) 0.085 (0.085, 0.085) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53- & AR- Hormone_therapies count 272 272 272 272
time 12 (9, 28) 12 (9, 28) 12 (9, 28) 12 (9, 28)
n 21 (15, 51) 4 (2, 10) 4 (2, 11) 4 (1, 11)
post_p 0.96 (0.82, 1) 0.71 (0.54, 0.87) 0.71 (0.54, 0.86) 0.63 (0.52, 0.78)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.039 (0.017, 0.062) 0.027 (0, 0.076) 0.017 (0, 0.064) 0 (0, 0.053)
Taxel_therapies count 5 5 5 5
time 11 (8, 12) 11 (8, 12) 11 (8, 12) 11 (8, 12)
n 22 (17, 25) 4 (3, 6) 2 (0, 3) 1 (0, 4)
post_p 0.76 (0.72, 0.8) 0.75 (0.68, 0.87) 0.57 (0.54, 0.66) 0.67 (0.57, 0.75)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.072 (0.059, 0.102) 0 (0, 0.072) 0 (0, 0.027) 0 (0, 0)
Carboplatin count 2 2 2 2
time 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10)
n 16 (15, 18) 2 (1, 4) 3 (3, 3) 4 (3, 6)
post_p 0.81 (0.76, 0.86) 0.63 (0.57, 0.69) 0.61 (0.55, 0.67) 0.78 (0.78, 0.79)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.065 (0.04, 0.09) 0.024 (0.005, 0.043) 0.062 (0.012, 0.112) 0 (0, 0)
Niraparib count 2 2 2 2
time 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13)
n 26 (21, 30) 2 (1, 4) 5 (5, 5) 5 (4, 6)
post_p 0.78 (0.77, 0.79) 0.54 (0.53, 0.55) 0.87 (0.82, 0.91) 0.72 (0.57, 0.87)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.092 (0.076, 0.108) 0.045 (0.009, 0.081) 0 (0, 0) 0 (0, 0)
TP53+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 6 (6, 6) 6 (6, 6) 1 (1, 1) 1 (1, 1) 1 (1, 1) 1 (1, 1) 2 (2, 2) 7 (7, 7)
post_p 0.87 (0.87, 0.87) 0.76 (0.76, 0.76) 0.53 (0.53, 0.53) NA (NA, NA) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.08 (0.08, 0.08) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1.02 (1.02, 1.02) 0.167 (0.167, 0.167) 0.055 (0.055, 0.055)
Taxel_therapies count 12 12 12 12 12 12 12 12
time 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16) 11 (8, 16)
n 10 (6, 18) 8 (5, 12) 2 (1, 3) 3 (1, 5) 3 (1, 4) 3 (1, 7) 2 (0, 3) 2 (0, 5)
post_p 0.78 (0.71, 0.9) 0.83 (0.73, 0.93) 0.58 (0.51, 0.7) 0.68 (0.52, 0.76) 0.64 (0.55, 0.83) 0.72 (0.57, 0.85) 0.53 (0.5, 0.7) 0.54 (0.52, 0.59)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.101 (0.08, 0.149) 0.034 (0, 0.057) 0.025 (0, 0.166) 0 (0, 0.073) 0.091 (0.046, 0.125) 0.01 (0, 0.068) 0 (0, 0.101) 0 (0, 0.068)
Carboplatin count 3 3 3 3 3 3 3 3
time 11 (9, 18) 11 (9, 18) 11 (9, 18) 11 (9, 18) 11 (9, 18) 11 (9, 18) 11 (9, 18) 11 (9, 18)
n 14 (7, 16) 4 (3, 5) 3 (2, 3) 1 (0, 6) 3 (2, 5) 1 (0, 3) 3 (1, 5) 5 (3, 5)
post_p 0.85 (0.57, 0.88) 0.69 (0.62, 0.74) 0.7 (0.56, 0.72) 0.69 (0.6, 0.78) 0.61 (0.58, 0.64) 0.56 (0.55, 0.57) 0.68 (0.55, 0.86) 0.72 (0.68, 0.8)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.136 (0.123, 0.142) 0 (0, 0.066) 0 (0, 0.047) 0 (0, 0) 0.067 (0.013, 0.145) 0.035 (0.007, 0.063) 0 (0, 0.03) 0 (0, 0.016)
Niraparib count 4 4 4 4 4 4 4 4
time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
n 12 (11, 14) 8 (5, 10) 2 (1, 4) 2 (1, 4) 2 (0, 4) 2 (2, 4) 2 (1, 3) 2 (1, 4)
post_p 0.76 (0.74, 0.85) 0.72 (0.66, 0.73) 0.7 (0.56, 0.79) 0.57 (0.5, 0.68) 0.6 (0.52, 0.67) 0.68 (0.57, 0.77) 0.74 (0.58, 0.86) 0.56 (0.53, 0.68)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.105 (0.078, 0.131) 0.08 (0.057, 0.126) 0.029 (0, 0.06) 0 (0, 0.025) 0.122 (0.076, 0.168) 0.056 (0.016, 0.065) 0 (0, 0) 0.027 (0.005, 0.033)
DRD+ Taxel_therapies count 3 3 3 3 3 3 3 3
time 13 (11, 14) 13 (11, 14) 13 (11, 14) 13 (11, 14) 13 (11, 14) 13 (11, 14) 13 (11, 14) 13 (11, 14)
n 4 (4, 5) 5 (4, 5) 4 (2, 5) 4 (3, 6) 1 (0, 3) 3 (2, 4) 1 (0, 1) 3 (2, 5)
post_p 0.54 (0.52, 0.55) 0.59 (0.55, 0.68) 0.61 (0.58, 0.67) 0.73 (0.65, 0.79) 0.64 (0.63, 0.64) 0.63 (0.57, 0.65) 0.56 (0.53, 0.58) 0.71 (0.67, 0.71)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.075 (0.058, 0.077) 0 (0, 0.024) 0.044 (0.009, 0.106) 0.043 (0.009, 0.054) 0.029 (0.006, 0.053) 0 (0, 0.081) 0 (0, 0) 0 (0, 0.044)
Carboplatin count 166 166 166 166 166 166 166 166
time 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32)
n 6 (3, 14) 5 (3, 15) 4 (2, 8) 4 (1, 9) 4 (1, 9) 4 (1, 8) 4 (2, 8) 4 (2, 8)
post_p 0.76 (0.58, 0.93) 0.71 (0.53, 0.83) 0.78 (0.57, 0.96) 0.71 (0.53, 0.88) 0.79 (0.58, 0.96) 0.7 (0.56, 0.88) 0.78 (0.59, 0.96) 0.72 (0.53, 0.87)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.028 (0, 0.061) 0.021 (0, 0.044) 0.025 (0, 0.066) 0.023 (0, 0.058) 0.025 (0, 0.068) 0.019 (0, 0.056) 0.034 (0, 0.076) 0.024 (0, 0.066)
Niraparib count 159 159 159 159 159 159 159 159
time 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32)
n 7 (3, 14) 7 (3, 16) 4 (1, 8) 4 (1, 9) 4 (2, 8) 4 (1, 8) 5 (1, 8) 4 (2, 8)
post_p 0.76 (0.57, 0.93) 0.73 (0.53, 0.87) 0.78 (0.55, 0.96) 0.72 (0.53, 0.89) 0.77 (0.57, 0.94) 0.71 (0.54, 0.9) 0.8 (0.58, 0.96) 0.72 (0.53, 0.92)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.029 (0, 0.057) 0.022 (0, 0.041) 0.03 (0, 0.068) 0.022 (0, 0.069) 0.031 (0, 0.076) 0.024 (0, 0.058) 0.029 (0, 0.064) 0.024 (0, 0.055)
TEfus+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 3 (3, 3) 5 (5, 5) 8 (8, 8) 1 (1, 1) 4 (4, 4) 4 (4, 4) 0 (0, 0) 0 (0, 0)
post_p 0.69 (0.69, 0.69) 0.77 (0.77, 0.77) 0.74 (0.74, 0.74) 0.54 (0.54, 0.54) 0.89 (0.89, 0.89) 0.66 (0.66, 0.66) NA (NA, NA) NA (NA, NA)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) 0.043 (0.043, 0.043) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.078 (0.078, 0.078) NA (NA, NA) NA (NA, NA)
Taxel_therapies count 167 167 167 167 167 167 167 167
time 15 (10, 31) 15 (10, 31) 15 (10, 31) 15 (10, 31) 15 (10, 31) 15 (10, 31) 15 (10, 31) 15 (10, 31)
n 5 (2, 13) 10 (5, 22) 5 (2, 12) 3 (1, 9) 4 (1, 9) 4 (2, 10) 3 (1, 7) 3 (1, 8)
post_p 0.75 (0.57, 0.9) 0.9 (0.73, 0.99) 0.69 (0.53, 0.83) 0.67 (0.52, 0.86) 0.78 (0.6, 0.97) 0.77 (0.57, 0.97) 0.66 (0.53, 0.83) 0.68 (0.52, 0.88)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.026 (0, 0.061) 0.037 (0, 0.069) 0.013 (0, 0.042) 0.008 (0, 0.064) 0.025 (0, 0.08) 0.028 (0, 0.076) 0.017 (0, 0.061) 0.019 (0, 0.063)
Carboplatin count 1 1 1 1 1 1 1 1
time 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14) 14 (14, 14)
n 3 (3, 3) 5 (5, 5) 5 (5, 5) 3 (3, 3) 5 (5, 5) 1 (1, 1) 3 (3, 3) 4 (4, 4)
post_p 0.73 (0.73, 0.73) 0.65 (0.65, 0.65) 0.78 (0.78, 0.78) 0.66 (0.66, 0.66) 0.51 (0.51, 0.51) 0.69 (0.69, 0.69) 0.89 (0.89, 0.89) 0.75 (0.75, 0.75)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.053 (0.053, 0.053) 0 (0, 0) 0 (0, 0) 0.158 (0.158, 0.158) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Niraparib count 3 3 3 3 3 3 3 3
time 9 (7, 12) 9 (7, 12) 9 (7, 12) 9 (7, 12) 9 (7, 12) 9 (7, 12) 9 (7, 12) 9 (7, 12)
n 2 (1, 4) 11 (9, 13) 4 (3, 5) 2 (1, 3) 2 (1, 3) 3 (1, 4) 2 (2, 3) 2 (2, 3)
post_p 0.52 (0.51, 0.56) 0.75 (0.72, 0.78) 0.7 (0.61, 0.75) 0.57 (0.56, 0.63) 0.6 (0.57, 0.68) 0.62 (0.53, 0.7) 0.54 (0.52, 0.83) 0.54 (0.53, 0.62)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0.093) 0.082 (0.041, 0.107) 0 (0, 0) 0 (0, 0) 0.093 (0.019, 0.122) 0.031 (0.006, 0.055) 0 (0, 0.03) 0 (0, 0.069)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 6 (6, 6) 1 (1, 1) 2 (2, 2) 4 (4, 4) 0 (0, 0) 2 (2, 2) 1 (1, 1) 2 (2, 2) 3 (3, 3) 4 (4, 4) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 2 (2, 2)
post_p 0.44 (0.44, 0.44) 0.46 (0.46, 0.46) 0.35 (0.35, 0.35) NA (NA, NA) NA (NA, NA) 0.25 (0.25, 0.25) NA (NA, NA) 0.37 (0.37, 0.37) NA (NA, NA) NA (NA, NA) 0.28 (0.28, 0.28) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.36 (0.36, 0.36) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.182 (0.182, 0.182) 0 (0, 0) 0.327 (0.327, 0.327) 0 (0, 0) NA (NA, NA) 0.194 (0.194, 0.194) 0 (0, 0) 0.246 (0.246, 0.246) 0.348 (0.348, 0.348) 0 (0, 0) 3.745 (3.745, 3.745) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.274 (0.274, 0.274) 0.489 (0.489, 0.489)
TP53- & AR- Taxel_therapies count 105 105 105 105
time 14 (9, 24) 14 (9, 24) 14 (9, 24) 14 (9, 24)
n 24 (15, 42) 4 (1, 8) 5 (2, 10) 5 (2, 10)
post_p 0.09 (0, 0.33) 0.45 (0.34, 0.49) 0.25 (0.05, 0.44) 0.4 (0.24, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.156 (0.123, 0.224) 0.095 (0.045, 0.213) 0.155 (0.085, 0.315) 0.058 (0.03, 0.146)
Carboplatin count 122 122 122 122
time 13 (9, 23) 13 (9, 23) 13 (9, 23) 13 (9, 23)
n 22 (15, 43) 4 (2, 10) 4 (2, 9) 5 (2, 9)
post_p 0.13 (0.01, 0.36) 0.28 (0.06, 0.46) 0.45 (0.34, 0.49) 0.4 (0.23, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.161 (0.121, 0.212) 0.164 (0.071, 0.384) 0.083 (0.042, 0.195) 0.06 (0.026, 0.147)
Niraparib count 110 110 110 110
time 13 (9, 21) 13 (9, 21) 13 (9, 21) 13 (9, 21)
n 21 (15, 38) 5 (2, 9) 4 (1, 9) 4 (2, 9)
post_p 0.16 (0.02, 0.43) 0.26 (0.05, 0.45) 0.42 (0.26, 0.49) 0.4 (0.25, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.152 (0.116, 0.208) 0.167 (0.087, 0.396) 0.082 (0.047, 0.182) 0.063 (0.022, 0.207)
TP53+ Hormone_therapies count 254 254 254 254 254 254 254 254
time 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32)
n 18 (8, 35) 11 (6, 23) 4 (1, 8) 4 (1, 8) 5 (1, 10) 5 (2, 10) 4 (1, 8) 4 (1, 8)
post_p 0.34 (0.1, 0.48) 0.19 (0.03, 0.42) 0.33 (0.12, 0.48) 0.24 (0.08, 0.45) 0.37 (0.19, 0.48) 0.33 (0.12, 0.47) 0.27 (0.09, 0.46) 0.25 (0.07, 0.43)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.178 (0.14, 0.263) 0.163 (0.113, 0.266) 0.174 (0.101, 0.434) 0.165 (0.076, 0.466) 0.201 (0.138, 0.443) 0.175 (0.098, 0.376) 0.19 (0.097, 0.467) 0.178 (0.086, 0.435)
Carboplatin count 3 3 3 3 3 3 3 3
time 13 (12, 15) 13 (12, 15) 13 (12, 15) 13 (12, 15) 13 (12, 15) 13 (12, 15) 13 (12, 15) 13 (12, 15)
n 13 (12, 22) 5 (4, 11) 0 (0, 2) 2 (2, 4) 4 (2, 6) 4 (4, 6) 1 (0, 1) 3 (1, 5)
post_p 0.28 (0.1, 0.28) 0.2 (0.11, 0.23) 0.46 (0.46, 0.46) 0.48 (0.35, 0.49) 0.39 (0.16, 0.39) 0.25 (0.19, 0.31) 0.44 (0.39, 0.49) 0.47 (0.46, 0.47)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.168 (0.155, 0.328) 0.192 (0.158, 0.232) 0.13 (0.13, 0.13) 0.027 (0.005, 0.072) 0.374 (0.246, 0.516) 0.221 (0.183, 0.316) 0.082 (0.016, 0.147) 0.049 (0.01, 0.058)
Niraparib count 3 3 3 3 3 3 3 3
time 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13)
n 10 (9, 15) 10 (8, 12) 2 (0, 3) 3 (2, 4) 2 (2, 3) 3 (1, 5) 1 (0, 1) 3 (1, 4)
post_p 0.4 (0.19, 0.45) 0.21 (0.11, 0.32) 0.44 (0.4, 0.48) 0.28 (0.25, 0.4) 0.37 (0.36, 0.39) 0.41 (0.34, 0.44) 0.48 (0.46, 0.49) 0.42 (0.42, 0.43)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.199 (0.159, 0.262) 0.188 (0.18, 0.214) 0.077 (0.049, 0.104) 0.178 (0.134, 0.245) 0.164 (0.144, 0.268) 0.125 (0.124, 0.336) 0.11 (0.022, 0.198) 0.085 (0.078, 0.093)
DRD+ Hormone_therapies count 75 75 75 75 75 75 75 75
time 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32)
n 5 (2, 10) 5 (2, 12) 4 (2, 7) 4 (1, 7) 4 (1, 8) 4 (1, 9) 4 (1, 7) 3 (1, 8)
post_p 0.4 (0.21, 0.49) 0.37 (0.18, 0.48) 0.3 (0.15, 0.47) 0.21 (0.07, 0.36) 0.29 (0.13, 0.48) 0.27 (0.08, 0.45) 0.3 (0.09, 0.44) 0.25 (0.07, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.086 (0.056, 0.146) 0.057 (0.036, 0.117) 0.2 (0.114, 0.413) 0.173 (0.093, 0.72) 0.183 (0.113, 0.393) 0.147 (0.081, 0.38) 0.199 (0.087, 0.406) 0.182 (0.078, 0.45)
Taxel_therapies count 7 7 7 7 7 7 7 7
time 18 (16, 33) 18 (16, 33) 18 (16, 33) 18 (16, 33) 18 (16, 33) 18 (16, 33) 18 (16, 33) 18 (16, 33)
n 6 (5, 17) 8 (7, 17) 2 (1, 9) 5 (2, 10) 5 (4, 10) 3 (0, 6) 6 (4, 8) 4 (1, 8)
post_p 0.17 (0.05, 0.38) 0.38 (0.28, 0.42) 0.29 (0.18, 0.4) 0.39 (0.22, 0.47) 0.15 (0.09, 0.27) 0.34 (0.25, 0.36) 0.39 (0.26, 0.47) 0.36 (0.2, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.118 (0.069, 0.204) 0.049 (0.045, 0.083) 0.191 (0.161, 1.214) 0.078 (0.058, 0.323) 0.194 (0.153, 0.424) 0.125 (0.062, 1.455) 0.131 (0.116, 0.18) 0.105 (0.04, 0.159)
TEfus+ Hormone_therapies count 93 93 93 93 93 93 93 93
time 22 (11, 35) 22 (11, 35) 22 (11, 35) 22 (11, 35) 22 (11, 35) 22 (11, 35) 22 (11, 35) 22 (11, 35)
n 5 (2, 12) 12 (6, 24) 5 (2, 12) 4 (1, 9) 6 (3, 10) 5 (2, 10) 4 (2, 9) 4 (2, 9)
post_p 0.42 (0.29, 0.49) 0.21 (0.04, 0.39) 0.39 (0.18, 0.49) 0.24 (0.07, 0.4) 0.29 (0.08, 0.47) 0.3 (0.09, 0.44) 0.24 (0.07, 0.45) 0.23 (0.06, 0.43)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.086 (0.055, 0.154) 0.163 (0.117, 0.238) 0.06 (0.032, 0.129) 0.168 (0.08, 0.43) 0.181 (0.104, 0.445) 0.185 (0.1, 0.398) 0.167 (0.073, 0.412) 0.146 (0.079, 0.489)
Carboplatin count 6 6 6 6 6 6 6 6
time 12 (12, 28) 12 (12, 28) 12 (12, 28) 12 (12, 28) 12 (12, 28) 12 (12, 28) 12 (12, 28) 12 (12, 28)
n 5 (4, 11) 7 (5, 21) 5 (4, 12) 4 (2, 5) 6 (2, 10) 6 (2, 10) 2 (0, 8) 2 (1, 4)
post_p 0.22 (0.1, 0.36) 0.26 (0.06, 0.39) 0.36 (0.21, 0.46) 0.38 (0.3, 0.42) 0.27 (0.1, 0.43) 0.25 (0.12, 0.31) 0.36 (0.18, 0.41) 0.45 (0.24, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.19 (0.119, 0.566) 0.167 (0.147, 0.291) 0.056 (0.039, 0.078) 0.071 (0.038, 0.087) 0.21 (0.17, 0.334) 0.182 (0.153, 0.517) 0.143 (0.076, 0.537) 0.067 (0.025, 0.332)
Niraparib count 11 11 11 11 11 11 11 11
time 19 (10, 25) 19 (10, 25) 19 (10, 25) 19 (10, 25) 19 (10, 25) 19 (10, 25) 19 (10, 25) 19 (10, 25)
n 5 (2, 7) 12 (7, 21) 5 (0, 9) 2 (0, 4) 6 (4, 10) 4 (3, 5) 2 (0, 7) 2 (1, 8)
post_p 0.25 (0.05, 0.4) 0.21 (0.11, 0.43) 0.39 (0.24, 0.48) 0.41 (0.28, 0.5) 0.32 (0.24, 0.42) 0.34 (0.24, 0.45) 0.46 (0.44, 0.49) 0.35 (0.27, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.189 (0.127, 0.526) 0.171 (0.113, 0.262) 0.067 (0.027, 0.084) 0.103 (0.042, 0.24) 0.18 (0.134, 0.397) 0.179 (0.115, 0.328) 0.071 (0.029, 0.918) 0.111 (0.077, 0.239)